Voxel‐based distribution of metabolic impairment in corticobasal degeneration
Identifieur interne : 004919 ( Main/Exploration ); précédent : 004918; suivant : 004920Voxel‐based distribution of metabolic impairment in corticobasal degeneration
Auteurs : Gaetan Garraux [Belgique] ; Eric Salmon [Belgique] ; Philippe Peigneux [Belgique] ; Alexandre Kreisler [France] ; Christian Degueldre [Belgique] ; Christian Lemaire [Belgique] ; Alain Destée [France] ; Georges Franck [Belgique]Source :
- Movement Disorders [ 0885-3185 ] ; 2000-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Cartographie, Homme.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Basal Ganglia Diseases (metabolism), Basal Ganglia Diseases (radionuclide imaging), Basal ganglion, Blood Glucose (metabolism), Brain (metabolism), Brain (radionuclide imaging), Brain Diseases, Metabolic (metabolism), Brain Diseases, Metabolic (radionuclide imaging), Cartography, Case-Control Studies, Cerebral cortex, Comparative study, Corticobasal degeneration, Degeneration, Emission tomography, Energy Metabolism, Female, Fluorodeoxyglucose F18 (diagnostic use), Human, Humans, Local cerebral glucose utilization, Male, Metabolism, Middle Aged, Nerve Net (metabolism), Neurodegenerative Diseases (metabolism), Neurodegenerative Diseases (radionuclide imaging), PET, Pathophysiology, Positron, Progressive supranuclear palsy, Radiopharmaceuticals (diagnostic use), Supranuclear Palsy, Progressive (metabolism), Supranuclear ophthalmoplegia, Tomography, Emission-Computed (methods).
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- chemical , metabolism : Blood Glucose.
- metabolism : Basal Ganglia Diseases, Brain, Brain Diseases, Metabolic, Nerve Net, Neurodegenerative Diseases, Supranuclear Palsy, Progressive.
- methods : Tomography, Emission-Computed.
- radionuclide imaging : Basal Ganglia Diseases, Brain, Brain Diseases, Metabolic, Neurodegenerative Diseases.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Energy Metabolism, Female, Humans, Male, Middle Aged.
Abstract
This report emphasizes the precise topographic distribution of cerebral metabolic impairment in corticobasal degeneration (CBD) and the pathophysiological differences between CBD and progressive supranuclear palsy (PSP). Statistical parametric mapping (SPM96) analysis of 18FDG positron emission tomography (PET) data was performed in 22 patients with CBD compared with 46 healthy subjects (HS) and 21 patients with PSP who were studied at rest. A statistical threshold of p <0.001 was fixed, further corrected for multiple or independent comparisons (p <0.05). In comparison with HS, the metabolic impairment in CBD was asymmetrically distributed in the putamen, thalamus, precentral (Brodmann's area, BA 4), lateral premotor (BA 6/44) and supplementary motor areas (SMA, BA 6), dorsolateral prefrontal (8/9/46) cortex, and the anterior part of the inferior parietal lobe (BA 40) including the intraparietal sulcus (BA 7/40). A similar hypometabolic pattern was observed for most individual analyses. When PSP was compared with CBD, metabolic impairment predominated in the midbrain, anterior cingulate (BA 24/32), and orbitofrontal regions (BA 10). The reverse contrast showed more posterior involvement in CBD (BA 6 and 5/7/40) including SMA. Our data suggest that multiple components of neural networks related to both movement execution and production of skilled movements are functionally disturbed in CBD compared with both HS and PSP.
Url:
DOI: 10.1002/1531-8257(200009)15:5<894::AID-MDS1021>3.0.CO;2-S
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000541
- to stream Istex, to step Curation: 000541
- to stream Istex, to step Checkpoint: 003119
- to stream Main, to step Merge: 007216
- to stream PascalFrancis, to step Corpus: 002B59
- to stream PascalFrancis, to step Curation: 000162
- to stream PascalFrancis, to step Checkpoint: 002A79
- to stream Main, to step Merge: 007471
- to stream PubMed, to step Corpus: 003F08
- to stream PubMed, to step Curation: 003F08
- to stream PubMed, to step Checkpoint: 003E33
- to stream Ncbi, to step Merge: 000343
- to stream Ncbi, to step Curation: 000343
- to stream Ncbi, to step Checkpoint: 000343
- to stream Main, to step Merge: 006F76
- to stream Main, to step Curation: 004919
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Voxel‐based distribution of metabolic impairment in corticobasal degeneration</title><author><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaetan" last="Garraux">Gaetan Garraux</name></author><author><name sortKey="Salmon, Eric" sort="Salmon, Eric" uniqKey="Salmon E" first="Eric" last="Salmon">Eric Salmon</name></author><author><name sortKey="Peigneux, Philippe" sort="Peigneux, Philippe" uniqKey="Peigneux P" first="Philippe" last="Peigneux">Philippe Peigneux</name></author><author><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name></author><author><name sortKey="Degueldre, Christian" sort="Degueldre, Christian" uniqKey="Degueldre C" first="Christian" last="Degueldre">Christian Degueldre</name></author><author><name sortKey="Lemaire, Christian" sort="Lemaire, Christian" uniqKey="Lemaire C" first="Christian" last="Lemaire">Christian Lemaire</name></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><country>France</country><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Franck, Georges" sort="Franck, Georges" uniqKey="Franck G" first="Georges" last="Franck">Georges Franck</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3A0AAFEC2DE2E4E7C7388AD4ADA17B8FDF8B80A8</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1002/1531-8257(200009)15:5<894::AID-MDS1021>3.0.CO;2-S</idno><idno type="url">https://api.istex.fr/document/3A0AAFEC2DE2E4E7C7388AD4ADA17B8FDF8B80A8/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000541</idno><idno type="wicri:Area/Istex/Curation">000541</idno><idno type="wicri:Area/Istex/Checkpoint">003119</idno><idno type="wicri:doubleKey">0885-3185:2000:Garraux G:voxel:based:distribution</idno><idno type="wicri:Area/Main/Merge">007216</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:00-0480404</idno><idno type="wicri:Area/PascalFrancis/Corpus">002B59</idno><idno type="wicri:Area/PascalFrancis/Curation">000162</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002A79</idno><idno type="wicri:doubleKey">0885-3185:2000:Garraux G:voxel:based:distribution</idno><idno type="wicri:Area/Main/Merge">007471</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:11009197</idno><idno type="wicri:Area/PubMed/Corpus">003F08</idno><idno type="wicri:Area/PubMed/Curation">003F08</idno><idno type="wicri:Area/PubMed/Checkpoint">003E33</idno><idno type="wicri:Area/Ncbi/Merge">000343</idno><idno type="wicri:Area/Ncbi/Curation">000343</idno><idno type="wicri:Area/Ncbi/Checkpoint">000343</idno><idno type="wicri:doubleKey">0885-3185:2000:Garraux G:voxel:based:distribution</idno><idno type="wicri:Area/Main/Merge">006F76</idno><idno type="wicri:Area/Main/Curation">004919</idno><idno type="wicri:Area/Main/Exploration">004919</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Voxel‐based distribution of metabolic impairment in corticobasal degeneration</title><author><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaetan" last="Garraux">Gaetan Garraux</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Cyclotron Research Center, University of Liège</wicri:regionArea><wicri:noRegion>University of Liège</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, University of Liège</wicri:regionArea><wicri:noRegion>University of Liège</wicri:noRegion></affiliation></author><author><name sortKey="Salmon, Eric" sort="Salmon, Eric" uniqKey="Salmon E" first="Eric" last="Salmon">Eric Salmon</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Cyclotron Research Center, University of Liège</wicri:regionArea><wicri:noRegion>University of Liège</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, University of Liège</wicri:regionArea><wicri:noRegion>University of Liège</wicri:noRegion></affiliation></author><author><name sortKey="Peigneux, Philippe" sort="Peigneux, Philippe" uniqKey="Peigneux P" first="Philippe" last="Peigneux">Philippe Peigneux</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Cyclotron Research Center, University of Liège</wicri:regionArea><wicri:noRegion>University of Liège</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, University of Liège</wicri:regionArea><wicri:noRegion>University of Liège</wicri:noRegion></affiliation></author><author><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Regional University Hospital of Lille</wicri:regionArea><wicri:noRegion>Regional University Hospital of Lille</wicri:noRegion><wicri:noRegion>Regional University Hospital of Lille</wicri:noRegion></affiliation></author><author><name sortKey="Degueldre, Christian" sort="Degueldre, Christian" uniqKey="Degueldre C" first="Christian" last="Degueldre">Christian Degueldre</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Cyclotron Research Center, University of Liège</wicri:regionArea><wicri:noRegion>University of Liège</wicri:noRegion></affiliation></author><author><name sortKey="Lemaire, Christian" sort="Lemaire, Christian" uniqKey="Lemaire C" first="Christian" last="Lemaire">Christian Lemaire</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Cyclotron Research Center, University of Liège</wicri:regionArea><wicri:noRegion>University of Liège</wicri:noRegion></affiliation></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, Regional University Hospital of Lille</wicri:regionArea><wicri:noRegion>Regional University Hospital of Lille</wicri:noRegion><wicri:noRegion>Regional University Hospital of Lille</wicri:noRegion><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Franck, Georges" sort="Franck, Georges" uniqKey="Franck G" first="Georges" last="Franck">Georges Franck</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology, University of Liège</wicri:regionArea><wicri:noRegion>University of Liège</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-09">2000-09</date><biblScope unit="vol">15</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="894">894</biblScope><biblScope unit="page" to="904">904</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">3A0AAFEC2DE2E4E7C7388AD4ADA17B8FDF8B80A8</idno><idno type="DOI">10.1002/1531-8257(200009)15:5<894::AID-MDS1021>3.0.CO;2-S</idno><idno type="ArticleID">MDS1021</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Basal Ganglia Diseases (metabolism)</term><term>Basal Ganglia Diseases (radionuclide imaging)</term><term>Basal ganglion</term><term>Blood Glucose (metabolism)</term><term>Brain (metabolism)</term><term>Brain (radionuclide imaging)</term><term>Brain Diseases, Metabolic (metabolism)</term><term>Brain Diseases, Metabolic (radionuclide imaging)</term><term>Cartography</term><term>Case-Control Studies</term><term>Cerebral cortex</term><term>Comparative study</term><term>Corticobasal degeneration</term><term>Degeneration</term><term>Emission tomography</term><term>Energy Metabolism</term><term>Female</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Human</term><term>Humans</term><term>Local cerebral glucose utilization</term><term>Male</term><term>Metabolism</term><term>Middle Aged</term><term>Nerve Net (metabolism)</term><term>Neurodegenerative Diseases (metabolism)</term><term>Neurodegenerative Diseases (radionuclide imaging)</term><term>PET</term><term>Pathophysiology</term><term>Positron</term><term>Progressive supranuclear palsy</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Supranuclear Palsy, Progressive (metabolism)</term><term>Supranuclear ophthalmoplegia</term><term>Tomography, Emission-Computed (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Brain</term><term>Brain Diseases, Metabolic</term><term>Nerve Net</term><term>Neurodegenerative Diseases</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Brain</term><term>Brain Diseases, Metabolic</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Energy Metabolism</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cartographie</term><term>Cortex cérébral</term><term>Dégénérescence</term><term>Etude comparative</term><term>Homme</term><term>Métabolisme</term><term>Noyau gris central</term><term>Ophtalmoplégie supranucléaire</term><term>Physiopathologie</term><term>Positon</term><term>Tomoscintigraphie</term><term>Utilisation cérébrale locale glucose</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cartographie</term><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This report emphasizes the precise topographic distribution of cerebral metabolic impairment in corticobasal degeneration (CBD) and the pathophysiological differences between CBD and progressive supranuclear palsy (PSP). Statistical parametric mapping (SPM96) analysis of 18FDG positron emission tomography (PET) data was performed in 22 patients with CBD compared with 46 healthy subjects (HS) and 21 patients with PSP who were studied at rest. A statistical threshold of p <0.001 was fixed, further corrected for multiple or independent comparisons (p <0.05). In comparison with HS, the metabolic impairment in CBD was asymmetrically distributed in the putamen, thalamus, precentral (Brodmann's area, BA 4), lateral premotor (BA 6/44) and supplementary motor areas (SMA, BA 6), dorsolateral prefrontal (8/9/46) cortex, and the anterior part of the inferior parietal lobe (BA 40) including the intraparietal sulcus (BA 7/40). A similar hypometabolic pattern was observed for most individual analyses. When PSP was compared with CBD, metabolic impairment predominated in the midbrain, anterior cingulate (BA 24/32), and orbitofrontal regions (BA 10). The reverse contrast showed more posterior involvement in CBD (BA 6 and 5/7/40) including SMA. Our data suggest that multiple components of neural networks related to both movement execution and production of skilled movements are functionally disturbed in CBD compared with both HS and PSP.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>France</li></country><region><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement><orgName><li>Université Lille 2</li><li>Université Lille Nord de France</li></orgName></list><tree><country name="Belgique"><noRegion><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaetan" last="Garraux">Gaetan Garraux</name></noRegion><name sortKey="Degueldre, Christian" sort="Degueldre, Christian" uniqKey="Degueldre C" first="Christian" last="Degueldre">Christian Degueldre</name><name sortKey="Franck, Georges" sort="Franck, Georges" uniqKey="Franck G" first="Georges" last="Franck">Georges Franck</name><name sortKey="Garraux, Gaetan" sort="Garraux, Gaetan" uniqKey="Garraux G" first="Gaetan" last="Garraux">Gaetan Garraux</name><name sortKey="Lemaire, Christian" sort="Lemaire, Christian" uniqKey="Lemaire C" first="Christian" last="Lemaire">Christian Lemaire</name><name sortKey="Peigneux, Philippe" sort="Peigneux, Philippe" uniqKey="Peigneux P" first="Philippe" last="Peigneux">Philippe Peigneux</name><name sortKey="Peigneux, Philippe" sort="Peigneux, Philippe" uniqKey="Peigneux P" first="Philippe" last="Peigneux">Philippe Peigneux</name><name sortKey="Salmon, Eric" sort="Salmon, Eric" uniqKey="Salmon E" first="Eric" last="Salmon">Eric Salmon</name><name sortKey="Salmon, Eric" sort="Salmon, Eric" uniqKey="Salmon E" first="Eric" last="Salmon">Eric Salmon</name></country><country name="France"><noRegion><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name></noRegion><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004919 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004919 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:3A0AAFEC2DE2E4E7C7388AD4ADA17B8FDF8B80A8
|texte= Voxel‐based distribution of metabolic impairment in corticobasal degeneration
}}
| This area was generated with Dilib version V0.6.23. |  |